Van Dyke publicly endorsed Bernie Sanders as his choice for the Democratic candidate in the 2016 US presidential election. Van Dyke, a New Deal Democrat, had not actively campaigned for a candidate since Eugene McCarthy in 1968. In July 2016, Van Dyke said of Donald Trump, "He has been a magnet to all the racists and xenophobes in the country, I haven't been this scared since the Cuban Missile Crisis. I think the human race is hanging in a delicate balance right now, and I'm just so afraid he will put us in a war. He scares me."
Alongside Angela Lansbury, Norman Lloyd, William Daniels, Christopher Lee, Mickey Rooney, Ernest Borgnine, Betty White, Edward Asner, Adam West, Marla Gibbs, William Shatner, Larry Hagman, Florence Henderson, Shirley Jones, Hal Linden and Alan Alda, Van Dyke is one of the few actors in Hollywood who lives into their 80s and/or 90s without ever either retiring from acting or having stopped getting work.
I've found a home here because actors have always said, 'He's really a dancer', and dancers said, 'No, no he's a singer', and singers said, 'No I think he's an actor.' I don't know, I was never that good at anything but I did a little bit of it all. I've never studied dancing but I've always loved to dance. I never sang anywhere except the shower and it took me forever to get into the high school choir. When I auditioned for Bye Bye Birdie (1963) I did a song and a little soft-shoe and for some reason they saw I could move. And I've never studied acting - which is maybe lucky otherwise I'd just be a copy of everybody else.
Van Dyke left high school in 1944, his senior year, intending to join the United States Army Air Forces for pilot training during World War II. Denied enlistment several times for being underweight, he was eventually accepted for service as a radio announcer before transferring to the Special Services and entertaining troops in the continental United States. He received his high school diploma in 2004 at the age of 78.