In Nuenen, Van Gogh focused on painting and drawing. Working outside and very quickly, he completed sketches and paintings of weavers and their cottages. From August 1884, Margot Begemann, a neighbour's daughter ten years his senior, joined him on his forays; she fell in love and he reciprocated, though less enthusiastically. They wanted to marry, but neither side of their families were in favour. Margot was distraught and took an overdose of strychnine, but survived after Van Gogh rushed her to a nearby hospital. On 26 March 1885, his father died of a heart attack.
By March 1882, Mauve appears to have gone cold towards Van Gogh, and stopped replying to his letters. He had learned of Van Gogh's new domestic arrangement with an alcoholic prostitute, Clasina Maria "Sien" Hoornik (1850–1904), and her young daughter. Van Gogh had met Sien towards the end of January 1882, when she had a five-year-old daughter and was pregnant. She had previously borne two children who died, but Van Gogh was unaware of this; on 2 July, she gave birth to a baby boy, Willem. When Van Gogh's father discovered the details of their relationship, he put pressure on his son to abandon Sien and her two children. Vincent at first defied him, and considered moving the family out of the city, but in late 1883, he left Sien and the children.
Van Gogh worked for Goupil in London from 1873 to May 1875 and in Paris from that date until April 1876. Daily contact with works of art aroused his artistic sensibility, and he soon formed a taste for Rembrandt, Frans Hals, and other Dutch masters, although his preference was for two contemporary French painters, Jean-François Millet and Camille Corot, whose influence was to last throughout his life. Van Gogh disliked art dealing. Moreover, his approach to life darkened when his love was rejected by a London girl in 1874. His burning desire for human affection thwarted, he became increasingly solitary. He worked as a language teacher and lay preacher in England and, in 1877, worked for a bookseller in Dordrecht, Netherlands. Impelled by a longing to serve humanity, he envisaged entering the ministry and took up theology; however, he abandoned this project in 1878 for short-term training as an evangelist in Brussels. A conflict with authority ensued when he disputed the orthodox doctrinal approach. Failing to get an appointment after three months, he left to do missionary work among the impoverished population of the Borinage, a coal-mining region in southwestern Belgium. There, in the winter of 1879–80, he experienced the first great spiritual crisis of his life. Living among the poor, he gave away all his worldly goods in an impassioned moment; he was thereupon dismissed by church authorities for a too-literal interpretation of Christian teaching.
There have been numerous debates as to the nature of Van Gogh's illness and its effect on his work, and many retrospective diagnoses have been proposed. The consensus is that Van Gogh had an episodic condition with periods of normal functioning. Perry was the first to suggest bipolar disorder in 1947, and this has been supported by the psychiatrists Hemphill and Blumer. Biochemist Wilfred Arnold has countered that the symptoms are more consistent with acute intermittent porphyria, noting that the popular link between bipolar disorder and creativity might be spurious. Temporal lobe epilepsy with bouts of depression has also been suggested. Whatever the diagnosis, his condition was likely worsened by malnutrition, overwork, insomnia and alcohol.
Van Gogh, the eldest of six children of a Protestant pastor, was born and reared in a small village in the Brabant region of the southern Netherlands. He was a quiet, self-contained youth, spending his free time wandering the countryside to observe nature. At 16 he was apprenticed to The Hague branch of the art dealers Goupil and Co., of which his uncle was a partner.
On January 27, 2013, at the age of 87, Van Dyke received the 2013 Screen Actors Guild Life Achievement Award. During his acceptance speech, Van Dyke reminisced about his work over the years as an entertainer and stated that his career has "been full of surprises and a lot of fun." He also praised actors working in the industry today, calling them "the greatest generation of actors" and telling them, "You've all lifted the art to another place now." He continued with a rhetorical question for his Hollywood colleagues: "Aren't we lucky to have found a line of work that doesn't require growing up? I love that." Van Dyke is the 49th recipient of the SAG Life Achievement Award, following 2012 honoree Mary Tyler Moore.