He incorporated his children and grandchildren into his TV endeavors. Son Barry Van Dyke, grandsons Shane Van Dyke and Carey Van Dyke along with other Van Dyke grandchildren and relatives appeared in various episodes of the long-running series Diagnosis: Murder. Although Stacy Van Dyke was not well known in show business, she made an appearance in the Diagnosis: Murder Christmas episode "Murder in the Family" (season 4) as Carol Sloan Hilton, the estranged daughter of Dr. Mark Sloan.
Van Dyke left high school in 1944, his senior year, intending to join the United States Army Air Forces for pilot training during World War II. Denied enlistment several times for being underweight, he was eventually accepted for service as a radio announcer before transferring to the Special Services and entertaining troops in the continental United States. He received his high school diploma in 2004 at the age of 78.